Familial Clustering of High Factor VIII Levels in Patients With Venous Thromboembolism
نویسندگان
چکیده
منابع مشابه
High Factor VIII Levels Independently Predict Venous Thromboembolism in Cancer Patients
Objective—Patients with cancer are at an increased risk for venous thromboembolism (VTE). Clotting factor VIII activity (FVIII) has been established as risk factor of primary and recurrent VTE. We investigated FVIII as predictive parameter of VTE in cancer patients. Methods and Results—The prospective observational Cancer and Thrombosis Study (CATS) includes patients with newly diagnosed cancer...
متن کاملHigh factor VIII levels independently predict venous thromboembolism in cancer patients: the cancer and thrombosis study.
OBJECTIVE Patients with cancer are at an increased risk for venous thromboembolism (VTE). Clotting factor VIII activity (FVIII) has been established as risk factor of primary and recurrent VTE. We investigated FVIII as predictive parameter of VTE in cancer patients. METHODS AND RESULTS The prospective observational Cancer and Thrombosis Study (CATS) includes patients with newly diagnosed canc...
متن کاملHigh factor VIII and the risk of venous thromboembolism.
There is now convincing evidence that a high level of coagulation factor VIII is an important risk factor for venous thromboembolism. A factor VIII plasma concentration above 1500 IU/l is associated with an almost 5-fold risk for a first episode of venous thrombosis. In thrombosis patients high factor VIII has been shown to persist over time and is not related to an acute phase reaction. High f...
متن کاملHigh factor VIII, von Willebrand factor, and fibrinogen levels and risk of venous thromboembolism in blacks and whites.
Venous thromboembolism (VTE) affects more than 300,000 people in the United States each year. However, it has been estimated that current diagnostic testing fails to identify prothrombotic risk in 50% of VTE patients. This article examines the relationship between levels of the pro-coagulant proteins factor VIII (FVIII), von Willebrand factor (VWF), and fibrinogen and risk of VTE in order to as...
متن کاملFamilial Clustering of Venous Thromboembolism – A Danish Nationwide Cohort Study
BACKGROUND Identification of risk factors for venous thromboembolism (VTE) is of utmost importance to improve current prophylactic regimes and treatment guidelines. The extent to which a family history contributes to the risk of VTE needs further exploration. OBJECTIVES To examine the relative rate of VTE in first-degree relatives compared with the general population. METHODS By crosslinkin...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2001
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.21.2.289